Oncogenic but non-essential role of N-myc downstream regulated gene 1 in the progression of esophageal squamous cell carcinoma
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چکیده
منابع مشابه
Oncogenic but non-essential role of N-myc downstream regulated gene 1 in the progression of esophageal squamous cell carcinoma
N-myc downstream regulated gene 1 (NDRG1/Cap43/Drg-1) has previously been shown to be dysregulated in esophageal squamous cell carcinoma (ESCC). In this study, we investigated the role of NDRG1 in the neoplastic progression of ESCC using ectopic gain-of-function and loss-of-function approaches. Stable transfectants of the KYSE30 ESCC cell line with altered NDRG1 levels were generated by lentivi...
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Objective(s): Epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as SWI/SNF. Brg1 also known as SMARCA4 is a catalytic subunit of SWI/SNF, which is necessary for MMPs expression. Matrix metalloproteinases (MMPs) are known as important player enzymes during tumor progression and metastasis. Aberrant epigenetic modification of chromatin should be...
متن کاملrole of brg1 in progression of esophageal squamous cell carcinoma
objective(s): epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as swi/snf. brg1 also known as smarca4 is a catalytic subunit of swi/snf, which is necessary for mmps expression. matrix metalloproteinases (mmps) are known as important player enzymes during tumor progression and metastasis. aberrant epigenetic modification of chromatin should be...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2013
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.22956